Assessment of the efficacy of Albendazole for the treatment of soil transmitted helminths in Timor-Leste

Albendazole (ALB) has been widely used in large-scale deworming programs to control infections with soil-transmitted helminths (STH). The scale up of chemotherapy programs will lead to increasing drug pressure on parasite populations, which will favour parasite genotypes that can resist anthelmintic drugs. Therefore it is imperative that monitoring programs are introduced, in order to detect any changes in therapeutic efficacy that may arise from the selection of worms carrying genes responsible for drug resistance. The aim of this study is to assess the anthelmintic efficacy of albendazole in communities in East Timor, prior to the implementation of a RCT that involved community deworming over a period of 2 years.