Meta-analysis of factors affecting adherence to lipid-lowering and blood-pressure-lowering pharmacotherapies for the primary prevention of cardiovascular disease.

Medication adherence is often poor and non-adherence is high among people receiving medications for the primary prevention of cardiovascular disease. A meta-analysis of over 20 studies published in the American Journal of Medicine in 2012 found that only half of patients adhered to primary prevention medications and there was no difference between drug classes, suggesting that side-effects are not the main driver of non-adherence. This meta-analysis will summarise the available evidence and quantify the effects of a range of sociodemographic and clinical factors on adherence to lipid-lowering and blood-pressure-lowering medications among people without established cardiovascular disease.